Their method now allows researchers to create unlimited PGCs, which were previously difficult to obtain, and this regular supply of treasured cells has helped to drive the study of mammalian reproduction. They have spent more than a decade piecing together the subtle details of mammalian gamete production and then recreating that process in vitro - all for the sake of science, not medicine. (Indeed, after the research was published, the editor of a gay and lesbian magazine e-mailed Hayashi for more information.)ĭespite the innovative nature of the research, the public attention surprised Hayashi and his senior professor, Mitinori Saitou.
MISSHAPEN EGGS SKIN
And it also suggested that men's skin cells could be used to create eggs, and that sperm could be generated from women's cells. He calls the live births a mere 'side effect' of the research, but that bench experiment became much more, because it raised the prospect of creating fertilizable eggs from the skin cells of infertile women. To prove that these laboratory-grown versions were truly similar to naturally occurring PGCs, he used them to create eggs, then used those eggs to create live mice. Starting with the skin cells of mice in vitro, he created primordial germ cells (PGCs), which can develop into both sperm and eggs.
The requests started trickling in after Hayashi published the results of an experiment that he had assumed would be of interest mostly to developmental biologists. One menopausal woman from England offered to come to his laboratory at Kyoto University in Japan in the hope that he could help her to conceive a child. Since last October, molecular biologist Katsuhiko Hayashi has received around a dozen e-mails from couples, most of them middle-aged, who are desperate for one thing: a baby.
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